Astrocyte elevated gene-1 induces protective autophagy
نویسندگان
چکیده
منابع مشابه
Astrocyte elevated gene-1 induces protective autophagy.
Astrocyte-elevated gene-1 (AEG-1) expression increases in multiple cancers and plays a crucial role in oncogenic transformation and angiogenesis, which are essential components in tumor cell development, growth, and progression to metastasis. Moreover, AEG-1 directly contributes to resistance to chemotherapeutic drugs, another important hallmark of aggressive cancers. In the present study, we d...
متن کاملبهینه سازی محصول PCRتوالی پروموترغنی ازG+C ژن انسانی Astrocyte elevated gene -1
چکیده زمینه و هدف: اکثر ژن‌های خانه‌دار، سرکوبگر تومور، و تقریبا 40% ژن‌های اختصاصی بافت‌ها حاوی توالی غنی از G+C در نواحی پروموتری خود می‌باشند که تکثیر آن با مشکلات زیادی همراه است. ژنAstrocyte elevated gene -1(AEG-1) دارای نقش عملکردی در چندین مرحله از پیشرفت تومور از جمله، ترانسفورماسیون، آپوپتوزیس، متاستاز، مقاومت به شیمی درمانی، رگزایی و پیری سلول می‌باشد. مواد و روش کار: این مطالعه، به ب...
متن کاملAstrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion.
The poor prognosis of malignant gliomas is largely attributed to their highly invasive nature. The molecular mechanism underlying the invasiveness of glioma cells, however, remains to be elucidated. The present study found that astrocyte elevated gene-1 (AEG-1) was upregulated in human glioma cell lines and glioma tissues compared with normal astrocytes and brain tissues. AEG-1 was found to be ...
متن کاملAstrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression.
Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by diverse etiology, activation of multiple signal transduction pathways, and various gene mutations. Here, we have determined a specific role for astrocyte elevated gene-1 (AEG1) in HCC pathogenesis. Expression of AEG1 was extremely low in human hepatocytes, but its levels were significantly increased in human ...
متن کاملMolecular mechanism of chemoresistance by astrocyte elevated gene-1.
Our recent findings show that astrocyte elevated gene-1 (AEG-1) is overexpressed in >90% of human hepatocellular carcinoma (HCC) samples, and AEG-1 plays a central role in regulating development and progression of HCC. In the present study, we elucidate a molecular mechanism of AEG-1-induced chemoresistance, an important characteristic of aggressive cancers. AEG-1 increases the expression of mu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1009479107